The tests for thiopurine methyltransferase (TPMT) enzyme activity or its underlying genetics are measured in people who are about to start treatment with a thiopurine drug. One or the other of these tests is used to identify individuals at risk of developing severe side effects from thiopurine therapy, such as suppression of the bone marrow that leads to reduced numbers of red blood cells, white blood cells and platelets.
ñIt may be possible for that parent to have another sperm or egg with the same mutation, pass that sperm or egg on to another child, and have a second child with the exact same genetic disease, î said Campbell. ñMosaicism can considerably increase the risk of a parent having a second child with the same apparently new genetic disease that a sibling has. î The study estimated that mothers with a mosaic mutation were 25 times more likely than fathers to have a second child with the same disorder. Those numbers increased even more if the mosaic mutation could be detected in the parent's bloodstream. Mothers with mosaicism in their blood were twice as likely to have a second child with the same disorder, and fathers with blood mosaicism were about 50 times more likely to have such a child.
allopurinol. Using this drug with azathioprine can increase the levels of azathioprine in your body and increase your risk of side effects. Your doctor may lower your dose of azathioprine if you're taking allopurinol.
febuxostat: Using this drug with azathioprine can increase the levels of azathioprine in your body and increase your risk of side effects. These medications shouldn't be used together.