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About TPMT (1,2,3A,3B,3C) Genotyping, AZA, 6MP, 6-Thioguanine test

TPMT (1,2,3A,3B,3C) Genotyping, AZA, 6MP, 6-Thioguanine test

₹9000 ₹7500

Know more about TPMT (1,2,3A,3B,3C) Genotyping, AZA, 6MP, 6-Thioguanine test

The tests for thiopurine methyltransferase (TPMT) enzyme activity or its underlying genetics are measured in people who are about to start treatment with a thiopurine drug. One or the other of these tests is used to identify individuals at risk of developing severe side effects from thiopurine therapy, such as suppression of the bone marrow that leads to reduced numbers of red blood cells, white blood cells and platelets.

Symptoms are :   nausea and vomiting

diarrhea

skin rash

fever

muscle aches

increased liver enzyme levels

liver damage

dizziness

low blood pressure. Symptoms of low blood pressure may include dizziness, feeling faint, and trouble breathing. 

Check regularly for the disease. 

Follow a healthy diet. 

Get regular exercise. 

Avoid smoking tobacco and too much alcohol. 

Get specific genetic testing that can help with diagnosis and treatment. 

ñIt may be possible for that parent to have another sperm or egg with the same mutation, pass that sperm or egg on to another child, and have a second child with the exact same genetic disease, î said Campbell. ñMosaicism can considerably increase the risk of a parent having a second child with the same apparently new genetic disease that a sibling has. î The study estimated that mothers with a mosaic mutation were 25 times more likely than fathers to have a second child with the same disorder. Those numbers increased even more if the mosaic mutation could be detected in the parent's bloodstream. Mothers with mosaicism in their blood were twice as likely to have a second child with the same disorder, and fathers with blood mosaicism were about 50 times more likely to have such a child.

allopurinol. Using this drug with azathioprine can increase the levels of azathioprine in your body and increase your risk of side effects. Your doctor may lower your dose of azathioprine if you're taking allopurinol. 

febuxostat: Using this drug with azathioprine can increase the levels of azathioprine in your body and increase your risk of side effects. These medications shouldn't be used together. 

Test Method 1 : The test requires a blood sample, which is drawn through a needle from a vein in your arm. 

Report available : Turn around time is 10 to 15 days. 

A person have the following symptoms should get this done:     nausea and vomiting

diarrhea

skin rash

fever

muscle aches

increased liver enzyme levels

liver damage

dizziness

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