There is currently no vaccine available for protection against hepatitis E infection. The following are recommended:
for people with hepatitis E, the exclusion period from childcare, preschool and work is not clear but it is reasonable to recommend the same exclusion period as for hepatitis A: 7 days after the onset of jaundice or illness
follow good personal hygiene practices, especially thorough hand washing
use good food handling procedures should always be followed do not eat raw fruit and raw vegetables unless you can peel them yourself
cooked food that is served hot is usually safe
only drink water that has been boiled or drink sealed bottled water
Prevention of Hepatitis E relies primarily on good sanitation and the availability of clean drinking water. Travelers to developing countries can reduce their risk for infection by not drinking unpurified water. Boiling and chlorination of water will inactivate HEV. Avoiding raw pork and venison can reduce the risk of HEV genotype 3 transmission. Immune globulin is not effective in preventing Hepatitis E.
Hepatitis E usually resolves on its own without treatment. There is no specific antiviral therapy for acute Hepatitis E. Physicians should offer supportive therapy. Patients are typically advised to rest, get adequate nutrition and fluids, avoid alcohol, and check with their physician before taking any medications that can damage the liver, especially acetaminophen. Hospitalization is sometimes required in severe cases and should be considered for pregnant women.
Few case reports and case series have indicated that modification of immunosuppressive medication and/or use of antiviral drugs may result in spontaneous viral clearance in immunocompromised patients with chronic hepatitis E.