GH testing is also used to detect excess GH and to help diagnose and monitor the treatment of acromegalyandgigantism Growth hormone (GH) testing is primarily used to identify growth hormone deficiency and to help evaluate pituitary gland functio
A growth hormone (GH) test measures the amount of human growth hormone in the blood GH is made by the pituitary gland and is needed for growth Growth hormone can cause the release of other substances that affect growth and metabolism. One of these is insulin-like growth factor
The secretion of growth hormone is regulated through a complex neuroendocrine control system especially by the functional interplay of two hypothalamichypophysiotropic hormones GH-releasing hormon and somatostatin exerting stimulatory and inhibitory influences, respectively, on the somatotrope. The two hypothalamicneurohormones are subject to modulation by a host ofneurotransmittersespecially the noradrenergic and cholinergic ones and other hypothalamic neuropeptides, and are the final mediators of metabolic, endocrine, neural, and immune influences for the secretion of GH. Since the identification of the GHRH peptide, recombinant DNA procedures have been used to characterize the corresponding cDNA and to clone GHRH receptor isoforms in rodent and human pituitaries.
Growth hormone deficiency is treated by replacing prescribed in NorthAmerica, Europe, and most of the rest of the world is a human GH manufactured byrecombinant DNA technology As GH is a large peptide molecule it must be injectedinton subcutaneous tissue or muscle to get it into the blood. Nearly painless insulin syringes make this less trying than is usually anticipated, but perceived discomfort is a subjective value When treated with GH a deficient child will begin to grow faster within months. Other benefits may be noticed, such as increased strength progress in motor development, and reduction of body fat. Side-effects of this type of physiologic replacement are quite rare.